Polynucleotide treatment is a skin rejuvenation procedure that involves injecting a substance called polynucleotides (PN), derived from salmon DNA, into the skin to promote healing, repair, and regeneration at a cellular level. One of the most well-known treatments in this category is Rejuran Healer Skinbooster, which is highly regarded for its ability to improve skin texture, elasticity, and overall health.
How do Polynucleotides work?
Polynucleotides (PN) are injected directly into the dermis (middle layer of the skin) through microinjections. These polynucleotides stimulate skin repair, collagen production, and overall regeneration, improving the skin’s texture, elasticity, and hydration.
Polynucleotides are fragments of DNA that act as building blocks for cellular repair and renewal. Polynucleotides are extracted from salmon because its molecular structure is highly biocompatible with human skin.
Some examples of Polynucleotides are Rejuran Healer Skinbooster and Plinest Skinbooster
The science behind Polynucleotides
Stimulation of Healing and Regeneration:
- Activates Fibroblasts: Fibroblasts in the skin are stimulated to produce more collagen and elastin, leading to improved skin elasticity and thickness.
- Promotes Cell Turnover: Damaged or aged skin cells are replaced with newer, healthier cells.
- Wound Healing: Encourages skin healing by promoting tissue repair at the cellular level.
Anti-Inflammatory Effects:
Polynucleotides have natural anti-inflammatory properties, reducing redness and irritation in the skin. This makes the treatment particularly beneficial for individuals with sensitive or inflamed skin.
Hydration Boost:
PN improves the skin’s moisture retention by strengthening the skin barrier, making it plumper and more hydrated.
Key benefits of Polynucleotides
Skin Healing: Repairs damaged skin cells and strengthens the skin’s natural barrier.
Collagen Stimulation: Improves skin elasticity and reduces the appearance of fine lines and wrinkles.
Improved Skin Texture: Enhances smoothness by reducing pore size and scars (e.g., acne scars).
Hydration: Retains moisture for a more plump and radiant appearance.
Anti-Aging: Slows the aging process by promoting healthier and more resilient skin.
How long do the results last?
After polynucleotide treatment, you may experience slight improvement in hydration and plumpness after a few days. Collagen stimulation and skin repair occur gradually, with optimal results visible after 4–6 weeks.
It is recommended to start with at least 3 treatments (once a month), followed by maintenance treatment every 4 to 6 months.
Results last about 4-6 months, depending on skin condition and lifestyle.
Polynucleotides and Hyaluronic acid: What are the differences?
Polynucleotides (PN) and Hyaluronic Acid (HA) are both popular substances used in skin rejuvenation treatments, but they work in fundamentally different ways and target distinct aspects of skin health.
| Feature | Polynucleotides (PN) | Hyaluronic Acid (HA) |
|---|---|---|
| Primary Function | Repair and regeneration | Hydration and volumizing |
| Mechanism | Stimulates collagen and healing | Retains moisture and plumps |
| Results | Gradual (4–6 weeks) | Immediate |
| Duration | 4-6 months | 6-9 months |
| Applications | Skin rejuvenation, scar repair | Dermal fillers, hydration |
| Suitability | Long-term repair | Instant plumping and hydration |
If you seek long-term repair, collagen stimulation, and subtle rejuvenation, Polynucleotides such as Rejuran skin booster is ideal.
If you prefer immediate results, hydration, or volume enhancement, Hyaluronic Acid may be a better option.
A consultation with a doctor can help determine the best choice based on your skin type, goals, and desired outcomes.
Who is this treatment suitable for?
Ideal candidates for Polynucleotides are:
Individuals with dull, tired, or aging skin.
Those looking to improve fine lines, wrinkles, or skin elasticity.
People with acne scars or other superficial skin imperfections.
What to expect during and after Polynucleotides treatment
Polynucleotides is administered using fine needles or an injector device. Numbing cream is applied to the treated area prior to injections.
The product is injected into the dermis (middle layer of the skin) in small amounts across the treatment area, typically the face, neck, or hands.
The procedure usually lasts 30–45 minutes, depending on the treatment area.
Expect mild redness, swelling, and tiny bumps at the injection sites. These typically subside within 1–3 days. You might feel a slight tenderness in the treated area, but it’s usually mild and temporary.
What is the recommended treatment regime?
A series of 3–4 sessions spaced 4 weeks apart is often recommended.
Maintenance treatments every 4-6 months help sustain improvements.
Possible side effects
Polynucleotide treatments are generally safe and well-tolerated due to the biocompatibility of polynucleotides (PN), which are derived from salmon DNA. However, like any medical procedure, there are potential side effects, mostly mild and temporary.
Common side effects are mild redness, swelling, small bumps and bruising which will resolve spontaneously in a short period of time.
More complicated side effects such as skin infection, allergies and hard nodules are very rare. It is important to get this procedure done by trained doctors for safety reasons.
Cost of Polynucleotide treatment in Singapore
Cost of Polynucleotide treatment in Singapore ranges from $300 – $800 in Singapore depending on the area of treatment.
Is Polynucleotides right for you?
Polynucleotides may be right for you if you seek long-term skin repair, natural rejuvenation, and subtle improvements in texture and elasticity. However, it’s not suitable for everyone, and factors like existing skin conditions, allergies, or expectations should be carefully considered. A consultation with an experienced practitioner at an aesthetic clinic in Singapore is the best way to determine if this treatment aligns with your goals.
A consultation with a qualified aesthetic professional is essential to assess your skin type, concerns, and suitability for this treatment. They can recommend the best treatment plan tailored to your needs.
